A. Wijaya et al., Effect of clindamycin therapy on phagocytic and oxidative activity profiles of spleen mononuclear cells in Babesia rodhaini-infected mice, J VET MED S, 63(5), 2001, pp. 563-566
Spleen weight, the number of spleen mononuclear cells, and their phagocytic
activity in groups of Babesia rodhaini-infected mice treated with diminaze
ne diaceturate and clindamycin increased significantly in the early stage o
f treatment, and then decreased in the final stage of treatment to approxim
ately the pre-infection level. The number of F4/80-positive macrophages and
their oxidative activity per mean whole-spleen weight also increased signi
ficantly during the course of treatment in comparison with the untreated gr
oup. The increases in the clindamycin-treated group were more prominent tha
n those in the group treated with diminazene diaceturate, suggesting the ef
fectiveness of clindamycin therapy for murine babesiosis.