Members of the Pbx family are involved in a diverse range of developmental
processes including axial patterning and organogenesis. Pbx Functions are i
n part mediated by the interaction of Pbx proteins with members of the Hox
and Meis/Prep families. We have identified a fourth mammalian Pbx family me
mber. Pbx4 in the mouse and PBX4 in humans are located on chromosome 8 and
chromosome 19, respectively. Pbx4 expression is confined to the testis, esp
ecially to spermatocytes in the pachytene stage of the first meiotic propha
se. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.