Association of cystic fibrosis, coeliac disease and alpha-1-antitrypsin deficiency in a child of 4 years

Background. Cystic fibrosis associated diseases as coeliac disease or alpha -1-antitrypsin deficiency may remain undetected for a long time,as the lea ding symptoms may be explained by the underlying basic disorder CF. Case report. We report on a 4 year old caucasian cystic fibrosis patient wi th additional alpha -1-antitrypsin deficiency and coeliac disease. If a pat ient with cystic fibrosis fails to thrive despite intensive treatment, addi tional disorders,for example coeliac disease, must be excluded by means of serology and histology. An alpha -1-antitrysin deficiency syndrom in cystic fibrosis patients with hepatic manifestation may accelerate the progressio n of liver cirrhosis and increase the risk of acquiring pseudomonas aerugin osa.