The allogeneic response and tumor immunity

The strong allogeneic response to donor MHC molecules in transplantation an d the weak response to tumor antigens represent two important and divergent but potentially interactive immune responses. A patient's response to allo geneic MHC molecules might promote an effective T-cell response to self MHC -restricted tumor peptides and the possibilities for this are discussed her e. These allogeneic responses might successfully be harnessed to promote th e immune eradication of metastatic cancer.