Ambulatory blood pressure monitoring (ABPM) in renal patients

High blood pressure is both a cause and a manifestation of renal disease. I t has an increasing prevalence among renal patients renal function is decli ning. Blood pressure is not a constant value, but it shows a high intrinsic and extrinsic variability. It is common to find striking discordances betw een blood pressure values and target organ damage. The average values obtai ned through ambulatory blood pressure monitoring (ABPM) are better related with cardiovascular morbility and mortality than office measurement, even i n renal disease patients. We report the experience with ABPM on 51 renal patients. None of them was o n renal replacement therapy. In 7 out of 14 non treated patients ABPM showe d clinic hypertension only. Mean age of truly hypertensive patients was hig her, but this difference was not significant (normotensive 31.7 +/- 17.1; h ypertensive 49.4 +/- 17.9 years, p < 0.1). There were no sex differences (n ormotensive, 5 males and 2 females; hypertensive, 4 males and 3 females). T hree normotensive patients had chronic renal failure, and as did 6 hyperten sive patients (p < 0.1). There were no differences in night-time drop eithe r for systolic (normotensive 3.7 +/- 3.5 hypertensive 6.1 +/- 8.9%) or for diastolic blood pressure (normotensive 10.4 +/- 4.7 hypertensive 6.2 +/- 8. 9%). Thirty seven patients who were on antihypertensive drug treatment: 23 (68.2 %) showed hypertension after the ABPM and 14 (37.8%) have normal blood pres sure values, more over, 4 of these 14 patients showed hypotension. There we re neither age differences between the groups (normotensive 49.0 +/- 12.5, hypertensive 57.9 +/- 15.4 years), nor sex differences (normotensive, 5 mal es and 5 females, hy pertensive 11 males and 12 females). The prevalence of renal failure was similar (normotensive, 85.7%; hipertensive, 82.6%). Mean night-time drop was not different (SBP, normotensive 6.1 +/- 7.6 hypcrtcns ive 7.2 +/- 7.6%; DBP: normotensive 9.0 +/- 8.3 hypertensive 13.5 +/- 7.6%) . ABPM is a helpful diagnostic tool in renal disease as in tile non complicat ed essential hypertension patient, both for experimental and for clinical p urposes.