Proton magnetic resonance spectroscopy in brain tumours: clinical applications

Parallel to the rapid development of clinical MRI, MR spectroscopy (MRS) ha s, after starting as an analytical tool used in chemistry and physics, evol ved to a noninvasive clinical examination. Most common neuroradiological di agnostic indications for MRS are functional inborn errors, neonatal hypoxia , ischaemia, metabolic diseases, white matter and degenerative diseases, ep ilepsy, inflammation, infections and intracranial neoplasm. Compared to CT and MRI, well-established morphological diagnostic tools, MRS provides info rmation on the metabolic state of brain tissue. We review the clinical impa ct of MRS in diagnosis of tumours and their differentiation from non-neopla stic lesions.