Cross-modal interactions are characteristic of normal perception. In this a
rticle, we discuss our work on cross-modal interactions between touch and v
ision in normally sighted humans. A region of extrastriate visual cortex, n
ear the parieto-occipital fissure, is not only active during but also neces
sary for tactile discrimination of grating orientation (but not spatial fre
quency). This is consistent with a role for visual imagery in certain aspec
ts of tactile perception. These findings have implications for the interpre
tation of visual cortical involvement in Braille reading by the blind.