Discriminative value of lipids and apolipoproteins in alcoholics

1. It is important to detect alcohol use in its early stages so that interv entions can be planned effectively. In a bid to screen for alcohol use diso rders various biochemical assessments have been advocated. 2. It has been seen that moderate to heavy alcohol consumption appears to e levate ApoA1 though the effect of alcohol consumption on ApoB is not well d efined. 3. Present study was planned to evaluate the contribution of lipid profile and lipoprotein measures for the diagnosis of alcohol use disorder in 75 al cohol dependent and 45 normal healthy controls. 4. Based on the TC,TG, HDL/LDL-c, HDL-c/TC, ApoA1, ApoB, and ApoA1/ApoB a d iscriminant equation was developed for classification of alcohol dependent users (alcoholics) and non- users (non-alcoholics). 5. The discriminant equation resulted in 84.7% of subjects being correctly classified. (94.7% in non-users and 81.1% in alcohol dependent users as alc oholics).