Catechol-O-methyltransferase is a candidate in the predisposition to schizo
phrenia both because of its function and the position of its gene. A multip
oint non-parametric linkage analysis and a transmission disequilibrium test
were performed on 42 multiplex families genotyped for Pml I and Eel I poly
morphisms using two definitions of the affected phenotype. Neither linkage
nor preferential transmission of any allele or haplotype was detected, fail
ing to replicate previous positive findings. (C) 2001 Elsevier Science Irel
and Ltd. All rights reserved.