Morphological and physiological characteristics of urethral circular and longitudinal smooth muscle

The urethral wall contains circular and longitudinal smooth muscle. Both la yers can develop spontaneous tone, and contract further or relax in respons e to excitatory or inhibitory stimuli. In the pig the cells do not generate action potentials, and the membranes possess L-type calcium channels and a variety of potassium channels which may modulate the membrane potential an d tone. The importance of these layers in generating the urethral pressure is not well understood in the human, but it seems likely that the circular smooth muscle is involved in generating urethral pressure in the pig.