A computer simulation of North American end-Pleistocene human and Large her
bivore population dynamics correctly predicts the extinction or survival of
32 out of 41 prey species. Slow human population growth rates, random hunt
ing, and Low maximum hunting effort are assumed; additional parameters are
based on published values. Predictions are close to observed values for ove
rall extinction rates, human population densities, game consumption rates,
and the temporal overlap of humans and extinct species. Results are robust
to variation in unconstrained parameters. This fully mechanistic model acco
unts for megafaunal extinction without invoking climate change and secondar
y ecological effects.