Solid-phase synthesis of glyco-oligonucleotide conjugates

Authors
Adinolfi, M De Napoli, L Di Fabio, G Guariniello, L Iadonisi, A Messere, A Montesarchio, D Piccialli, G
Citation
M. Adinolfi et al., Solid-phase synthesis of glyco-oligonucleotide conjugates, SYNLETT, (6), 2001, pp. 745-748
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
6
Year of publication
2001
Pages
745 - 748
Database
ISI
SICI code
0936-5214(200106):6<745:SSOGC>2.0.ZU;2-2
Abstract
The first examples of direct glycosidation of the 5'-OH end of polypyrimidi ne oligonucleotides still attached to the CPG solid support are reported. A general re-elongation solid phase procedure has been developed to successf ully isolate the target 5'-glycosyl derivatives. A 3',5'-diglucosylated 16- mer oligonucleotide has also been obtained.