A convenient selective N-alkylation of 4-oxo-1,4-dihydro-2-quinoline carboxylic acid

Authors
Edmont, D Chenault, J
Citation
D. Edmont et J. Chenault, A convenient selective N-alkylation of 4-oxo-1,4-dihydro-2-quinoline carboxylic acid, SYNLETT, (6), 2001, pp. 833-835
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
6
Year of publication
2001
Pages
833 - 835
Database
ISI
SICI code
0936-5214(200106):6<833:ACSNO4>2.0.ZU;2-O
Abstract
The selective N-alkylation of 4-oxo-1,4-dihydro-2-quinoline carboxylic acid has been achieved from 1,2-dihydro[1,4]oxazino[4,3-a]quinoline-4,6-dione b y the 2-morpholinone ring opening. In the same time, we have developed a ne w methodology to obtain the 1,2-dihydro[ 1,4]oxazino[4,3-a]quinoline-4,6-di one that involves an intramolecular cyclization of the 2-choroethyl 6-fluor o-4-oxo-1,4-dihydro-2-quinoline carboxylate.