Flow-injection system for automated dissolution testing of isoniazid tablets with chemiluminescence detection

A simple and sensitive flow-injection chemiluminescence (CL) system for aut omated dissolution testing is described and evaluated for monitoring of dis solution profiles of isoniazid tablets. The undissolved suspended particles in the dissolved solution were eliminated via on-line filter. The novel CL system of KIO4-isoniazid was also investigated. The sampling frequency of the system was 120 h (- 1). The dissolution profiles of isoniazid fast-rele ase tablets from three sources were determined, which demonstrates the stab ility, great sensitivity, large dynamic measuring range and robustness of t he system. (C) 2001 Elsevier Science B.V. All rights reserved.