Flow-injection chemiluminometric analysis of some benzamides by their sensitizing effect on the cerium-sulphite reaction

A simple, highly sensitive chemiluminescent method using flow injection is described for the determination of three substituted benzamides, namely: su lpiride, sultopride and tiapride. The method is based on the sensitizing ef fect of these drugs on the chemiluminometric oxidation of sulphite by ceriu m(IV). The different experimental parameters affecting the chemiluminescenc e intensity were carefully studied and incorporated into the procedure. The method permits the determination of 0.05-2.5 mug ml(-1) sulpiride, 0.01-2. 5 mug ml(-1) sultopride hydrochloride and 0.01-1.5 mug ml(-1) tiapride hydr ochloride with minimum detectability of 0.01 mug ml(-1). The method was app lied to the determination of these benzamides in pharmaceutical preparation s and biological fluids. (C) 2001 Elsevier Science B.V. All rights reserved .