Determination of palladium by graphite furnace atomic absorption spectroscopy without matrix matching

A graphite furnace atomic absorption spectroscopy method for the analysis o f the palladium (Pd) content in bulk pharmaceutical drug substances and the ir intermediates prepared in aqueous solutions is extended to samples prepa red in acetonitrile (ACN) and ACN-water mixtures as well to samples prepare d in dimethyl sulfoxide (DMSO) and DMSO-water mixtures. The Pd content in s amples solubilized in these solvents can be accurately determined with cali bration established with standards prepared in aqueous solutions without ma trix matching or using the method of standard additions. The validity of th is method is demonstrated by spike recovery studies and by the agreement wi th results for the same samples prepared in these solvents, in concentrated nitric acid, and prepared by a microwave digestion system. (C) 2001 Elsevi er Science B.V. All rights reserved.