Background-The development of asthma seems to be influenced by the adoption
of a Western lifestyle. A study was undertaken to assess the importance of
indoor environmental factors in Nepal where the lifestyle and home environ
ment differ from that in the West.
Methods-The home environment of 121 schoolchildren with asthma and 126 cont
rols aged 11-17 years was studied. The homes of all participants were inves
tigated and the children and their mothers were interviewed using a standar
dised questionnaire. Cases and controls were identified from an ISAAC (Inte
rnational Study of Asthma and Allergy in Childhood) based population study
of 2330 schoolchildren in Kathmandu, Nepal.
Results-Keeping cattle inside the house during the night was related to a l
ower risk for having asthma (adjusted odds ratio (OR) 0.2 (95% CI 0.1 to 0.
5)) while there was no association between asthma and cattle kept outside.
Asthma was associated with cigarette smoking by two or more family members
(OR 1.9 (95% CI 1.0 to 3.9)) and with the domestic use of smoky fuels (OR 2
.2 (95% CI 1.0 to 4.5)). In analyses stratified by sex, passive smoking and
the use of smoky fuels were significantly associated with asthma only in b
oys.
Conclusions-The risk of asthma in Nepalese children was lower in subjects e
xposed to cattle kept inside the house and higher in subjects exposed to pa
ssive smoking and indoor use of smoky fuels. Childhood exposure to microorg
anisms or allergens from cattle may protect against the development of atop
ic disease.