The effect of zearalenone on some enzymatic parameters in rabbits

The effects of low (10 mug/kg b.w.) and high (100 mug/kg b.w.) doses of myc otoxin-zearalenone on selected blood serum enzyme activities of aspartate a minotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), and total lactatedehydrogenase (LD ) of rabbits were studied. The toxin was administered orally for 14 days. I n the experimental group E, (10]Ig:kg b.w.), a significant increase in ALP activity was observed at 168 and 336 h during the experiment. In the 100 mu g zearalenone sera (group E), significant increases in activities of AST. A LT, ALP. GGT. and LD were observed at 168 and 336 h, indicating possible li ver toxicity due to chronic effects of the toxin. (C) 2001 Elsevier Science Ireland Ltd. Ail rights reserved.