In this paper, we show that for several second-order partial differential e
quations
L[u] =A(x, y)u(xx) + 2B(x,y)u(xy) + C(x,y)u(yy) + D(x,y)u(x) + E(x,y)u(y) =
lambda (n)u
which have orthogonal polynomial eigenfunctions, these polynomials can be e
xpressed as a product of two classical orthogonal polynomials in one variab
le. This is important since, otherwise, it is very difficult to explicitly
find formulas for these polynomial solutions. From this observation and cha
racterization, we are able to produce additional examples of such orthogona
l polynomials together with their orthogonality that widens the class found
by H. L. Krall and Sheffer in their seminal work in 1967. Moreover, from o
ur approach, we can answer some open questions raised by Krall and Sheffer.