PROTEINS THAT BIND TO DOUBLE-STRANDED REGIONS OF TELOMERIC DNA

In budding yeast, the DNA-binding protein Rap1p orchestrates a negativ e feedback on regulation of telomere length and the organization of a heterochromatin-like telomeric compartment. Recent studies have led to the identification of functionally related telomeric proteins from fi ssion yeast and mammals. These advances underline the key role played by the proteins that bind to the duplex part of telomeric DNA and reve al an important structural diversity among telomeric proteins.