MAMMALIAN-CELL MUTANTS OF MEMBRANE PHOSPHOLIPID BIOGENESIS

Authors
NISHIJIMA M KUGE O HANADA K
Citation
M. Nishijima et al., MAMMALIAN-CELL MUTANTS OF MEMBRANE PHOSPHOLIPID BIOGENESIS, Trends in cell biology, 7(8), 1997, pp. 324-329
Citations number
44
Categorie Soggetti
Cell Biology
Journal title
Trends in cell biology → ACNP
ISSN journal
09628924
Volume
7
Issue
8
Year of publication
1997
Pages
324 - 329
Database
ISI
SICI code
0962-8924(1997)7:8<324:MMOMPB>2.0.ZU;2-C
Abstract
Cultured mammalian cell mutants defective in the biosynthesis of membr ane phospholipids, although limited in number, are increasing our unde rstanding of the molecular mechanisms underlying the biogenesis and th e biological significance of membrane phospholipids in higher eukaryot es. This review summarizes the progress in the isolation and character ization of such mutants, focusing on those isolated from cultured Chin ese hamster ovary (CHO) cells.