Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium

AIM: To investigate the anti-implantation mechanism of mifepriston. METHODS : In situ hybridization and immunohistochemistry were applied to determine mRNA and protein. RESULTS: After mifepriston injection, the number of impla ntation sites were obviously reduced, mifepriston could inhibit the embryo implantation in mouse, The expression of apoptosis related genes, Fas and F ast, in mouse endometrium was also decreased after mifepriston treatment. C ONCLUSION: The expression of apoptosis related genes Fas and Fast is regula ted by mifepriston and the inhibitory effect of mifepriston on the embryo i mplantation may be mediated by action on the Fas/FasL system.