Activated protein C and inflammation in human myocardium after heart surgery

Citation
J. Petaja et al., Activated protein C and inflammation in human myocardium after heart surgery, AM J HEMAT, 67(3), 2001, pp. 210-212
Citations number
10
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF HEMATOLOGY
ISSN journal
03618609 → ACNP
Volume
67
Issue
3
Year of publication
2001
Pages
210 - 212
Database
ISI
SICI code
0361-8609(200107)67:3<210:APCAII>2.0.ZU;2-9
Abstract
To assess possible interactions between inflammation and activation of the anticoagulant protein C system during post-ischemic reperfusion protein C, APC, neutrophil L-selectin expression and myocardial myeloperoxidase activi ty (MPO) were measured in 19 patients undergoing cardiopulmonary bypass. Af ter reperfusion for 10 min, APC to protein C ratio (APC/PC) increased from pre-reperfusion value 1.43 +/- 0.12 (mean +/- SEM) to 2.25 +/- 0.29, p = 0. 015, Negative correlations were observed between APC/PC and MPO activity (S pearman r -0.64, p = 0.007) and APC/PC and neutrophil L-selectin expression (r = -0.7, p = 0.007, demonstrating that post-ishemic protein C activation was associated with decreased neutrophil tissue sequestration. Thus, physi ological protein C activation may be involved in regulation of the inflamma tory injury during reperfusion of human ischemic coronary circulation, (C) 2001 Wiley-Liss, Inc.