Pc. Sham et S. Purcell, Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs, AM J HU GEN, 68(6), 2001, pp. 1527-1532
Citations number
9
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Molecular Biology & Genetics
The Haseman-Elston regression method offers a simpler alternative to varian
ce-components (VC) models, for the linkage analysis of quantitative traits.
However, even the "revisited" method, which uses the cross-product-rather
than the squared difference-in sib trait values, is, in general, less power
ful than VC models. In this report, we clarify the relative efficiencies of
existing Haseman-Elston methods and show how a new Haseman-Elston method c
an be constructed to have power equivalent to that of VC models. This metho
d uses as the dependent variable a linear combination of squared sums and s
quared differences, in which the weights are determined by the overall trai
t correlation between sibs in a population. We show how this method can be
used for both the selection of maximally informative sib pairs for genotypi
ng and the subsequent analysis of such selected samples.