SPECTRAL-ANALYSIS OF A THALAMUS-TO-CORTEX SEIZURE PATHWAY

Physiological evidence has shown that the anterior thalamus (AN) and i ts associated efferents/afferents constitute an important propagation pathway for one animal model of generalized tonic-clonic epileptic sei zures, In this study we extend and confirm the support for AN's role b y examining neuro-electric signal indicators during seizure episodes, We show that the electroencephalogram (EEG) recorded from AN is highly coherent with the EEG derived from the cortex (CTX), By removing the effects of another thalamic nucleus, posterior thalamus (PT)-unaffilia ted with the tract linking AN to cortex-partial coherence analysis lea ves the CTX/AN coherence undiminished, The most robust band of strong CTX-AN coherence is centered around the spike-wave pacing frequency of 1-3 Hz. Partial-multiple coherence analysis techniques are used to re move the possible signal contributions from hippocampus in addition to PT, The CTX-AN coherence still remains undiminished in the low-freque ncy bands, Conclusive evidence from coherence studies and other spectr al measures reaffirm the special role of the AN in the propagation of seizure activity from subcortex to cortex.