MODIFIED ABIETANE DITERPENOIDS AND A METHOXYLUPANE DERIVATIVE FROM SALVIA-PALAESTINA

Two new abietane diterpenoids, 2-oxocandesalvone A and salvipalestinoi c acid, and a new methoxylupane derivative have been isolated from the aerial parts of Salvia palaestina. Several previously known triterpen es and abietane diterpenes have also been found in the same plant, tog ether with sitosterol, 5-hydroxy-7,4'-dimethoxyflavone and a mixture o f fatty acid esters of tyrosol. The structures of the new compounds [1 1,12,14-trihydroxy-19(4 --> 3)-abeo-3,8,11,13-abietatetraen-2,7-dione (2-oxocandesalvone A), -oxo-2,3-seco-8,11,13-abietatrien-2,11-olide-3- oic acid (salvipalestinoic acid) and 2 alpha-methoxylup-20(29)-en-3 be ta-ol] were established by spectroscopic means. (C) 1997 Elsevier Scie nce Ltd. All rights reserved.