Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells

Authors
Yoshida, H Teramoto, T Ikeda, K Yamori, Y
Citation
H. Yoshida et al., Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells, BIOS BIOT B, 65(5), 2001, pp. 1211-1213
Citations number
13
Categorie Soggetti
Agricultural Chemistry","Biochemistry & Biophysics
Journal title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN journal
09168451 → ACNP
Volume
65
Issue
5
Year of publication
2001
Pages
1211 - 1213
Database
ISI
SICI code
0916-8451(200105)65:5<1211:GEOSTP>2.0.ZU;2-N
Abstract
Glycitein, as one of the three major isoflavones in soybeans, directly but significantly (about 5%) suppressed the proliferation of MC3T3-E1 and stimu lated bone-related protein (alkaline phosphatase (ALP) and osteocalcin (OC) ) expression. These results indicate that glycitein suppresses the prolifer ation of osteoblasts and promotes differentiation from its progenitor.