Severe combined immunodeficiency mouse-human skin chimeras: a unique animal model for the study of psoriasis and cutaneous inflammation

Citation
Sp. Raychaudhuri et al., Severe combined immunodeficiency mouse-human skin chimeras: a unique animal model for the study of psoriasis and cutaneous inflammation, BR J DERM, 144(5), 2001, pp. 931-939
Citations number
74
Categorie Soggetti
Dermatology,"da verificare
Journal title
BRITISH JOURNAL OF DERMATOLOGY
ISSN journal
00070963 → ACNP
Volume
144
Issue
5
Year of publication
2001
Pages
931 - 939
Database
ISI
SICI code
0007-0963(200105)144:5<931:SCIMSC>2.0.ZU;2-C
Abstract
Elucidation of the molecular and cellular mechanisms responsible for the pa thogenesis of psoriasis had been significantly handicapped due to lack of a n ideal animal model. To overcome this hurdle several investigators have de veloped a number of animal models for psoriasis. Recent establishment of th e SCID-human skin chimeras with transplanted psoriasis plaques has opened n ew vistas to study the molecular complexities involved in psoriasis. This m odel also offers a unique opportunity to investigate various key biological events such as cell proliferation, angiogenesis, homing in of T cells in t arget tissues, neurogenic inflammation and cytokine/chemokine cascades invo lved in an inflammatory reaction. The SCID mouse model will be of immense h elp to target the cellular and molecular events associated with these patho genic processes and develop novel drugs for psoriasis and other inflammator y diseases. In this article we have reviewed the prospects and the limitati ons of the SCID mouse model of psoriasis.