Adolescent-onset ichthyosiform-like erythroderma with lichenoid tissue reaction: a new entity?

A patient with severe ichthyosiform erythroderma and lichenoid histological changes is presented. We discuss the clinical and histological differentia l diagnosis, including lupus erythematosus, lichenoid drug eruption, lichen planus, graft-versus-host disease, lymphoma, keratosis lichenoides chronic a, Netherton's syndrome and ichthyosiform erythroderma. None of these is co nsistent with the features in our case, which may represent either a hither to unreported form of ichthyosiform erythroderma or possibly a new entity.