Acute myeloid leukemia with t(5;18)(q35;q21)

A case of acute myelocytic leukemia with a translocation (5;18)(q35;q21) is reported. Cytogenetic abnormalities of the long arm of chromosome 5 have l ong been known to affect hematopoiesis. Although translocations between 5q and other chromosomes have been associated with malignancy, this is the fir st reported case of a t(5;18) resulting in acute myeloid leukemia. Possible molecular mechanisms underlying the pathogenesis of the disease are discus sed. (C) 2001 Elsevier Science Inc. All rights reserved.