Acute myeloid leukemia with concomitant trisomies 4 and 10: a distinctive form of myeloid leukemia?

The occurrence of trisomy 4 or trisomy 10 as the sole chromosomal abnormali ty in acute myeloid leukemia (AML) is very rare, the reported frequency bei ng less than 1%. We describe two cases of AML-M2 with concomitant trisomy 4 and trisomy 10, a hitherto undescribed phenomenon. They showed two unusual features, including immunoreactivity for CD56 and a short-lived but rapidl y progressive myelodysplastic phase preceding the appearance of frank leuke mia. These findings raise the possibility that AML with concommitant trisom y 4 and trisomy 10 may constitute a distinctive subtype of AML. (C) 2001 El sevier Science Inc. All rights reserved.