Treatment effects on carbon dioxide retention in patients with obstructivesleep apnea-hypopnea syndrome

Citation
F. Han et al., Treatment effects on carbon dioxide retention in patients with obstructivesleep apnea-hypopnea syndrome, CHEST, 119(6), 2001, pp. 1814-1819
Citations number
27
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
CHEST
ISSN journal
00123692 → ACNP
Volume
119
Issue
6
Year of publication
2001
Pages
1814 - 1819
Database
ISI
SICI code
0012-3692(200106)119:6<1814:TEOCDR>2.0.ZU;2-S
Abstract
Objectives: This study was designed to examine respiratory control in patie nts with obstructive sleep apnea-hypopnea syndrome (OSAHS), with or without CO2 retention. Methods: We recruited 10 body mass index-matched, apnea-hypopnea index-matc hed, age-matched, and lung function-matched OSAHS patients, according to th eir awake PaCO2. Five patients were hypercapnic (PaCO2, greater than or equ al to 45 mm Hg), and five patients were eucapnic. Hypoxic responses (the ra tio of the change in minute ventilation [Delta (V) over dot E] to the chang e in arterial oxygen saturation [Delta Sao(2)] and the ratio of the change in mouth occlusion pressure over the first 100 ms of inspiration against an occluded airway [DeltaP(0.1)] to Delta Sao(2)) and hypercapnic responses ( Delta (V) over dotE/Delta PCO2 ratio and Delta P0.1/Delta PCO2 ratio) were tested during wakefulness before treatment in all 10 patients, and before a nd during treatment (at 2, 4, and 6 weeks) with pressure support in the hyp ercapnic group. Results: Hypercapnic patients had lower mean (+/- SD) Delta (V) over dotE/D elta SaO(2) ratio than eucapnic patients (-0.17 +/- 0.04 vs -0.34 +/- 0.04 L/min/%SaO(2), respectively), lower mean DeltaP(0.1)/Delta SaO(2) ratio (-0 .04 +/- 0.02 vs -0.14 +/- 0.03 cm H2O/%SaO(2), respectively), and lower Del taP(0.1)/Delta PCO2, ratio (0.23 +/- 0.1 vs 0.49 +/- 0.1 cm H2O/mm Hg, resp ectively) [p < 0.05]. After receiving noninvasive ventilation treatment, th e hypercapnic and hypoxic responses of the hypercapnic patients increased. At 4 to 6 weeks, values for both responses had increased to within the norm al range and PaCO2 had fallen to < 45 mm Hg, while weight was unchanged. Conclusions: Depressed chemoresponsiveness plays a role that is independent of obesity in the development of CO2 retention in some OSAHS patients, and it may be a response to sleep-disordered breathing.