F. Han et al., Treatment effects on carbon dioxide retention in patients with obstructivesleep apnea-hypopnea syndrome, CHEST, 119(6), 2001, pp. 1814-1819
Citations number
27
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Objectives: This study was designed to examine respiratory control in patie
nts with obstructive sleep apnea-hypopnea syndrome (OSAHS), with or without
CO2 retention.
Methods: We recruited 10 body mass index-matched, apnea-hypopnea index-matc
hed, age-matched, and lung function-matched OSAHS patients, according to th
eir awake PaCO2. Five patients were hypercapnic (PaCO2, greater than or equ
al to 45 mm Hg), and five patients were eucapnic. Hypoxic responses (the ra
tio of the change in minute ventilation [Delta (V) over dot E] to the chang
e in arterial oxygen saturation [Delta Sao(2)] and the ratio of the change
in mouth occlusion pressure over the first 100 ms of inspiration against an
occluded airway [DeltaP(0.1)] to Delta Sao(2)) and hypercapnic responses (
Delta (V) over dotE/Delta PCO2 ratio and Delta P0.1/Delta PCO2 ratio) were
tested during wakefulness before treatment in all 10 patients, and before a
nd during treatment (at 2, 4, and 6 weeks) with pressure support in the hyp
ercapnic group.
Results: Hypercapnic patients had lower mean (+/- SD) Delta (V) over dotE/D
elta SaO(2) ratio than eucapnic patients (-0.17 +/- 0.04 vs -0.34 +/- 0.04
L/min/%SaO(2), respectively), lower mean DeltaP(0.1)/Delta SaO(2) ratio (-0
.04 +/- 0.02 vs -0.14 +/- 0.03 cm H2O/%SaO(2), respectively), and lower Del
taP(0.1)/Delta PCO2, ratio (0.23 +/- 0.1 vs 0.49 +/- 0.1 cm H2O/mm Hg, resp
ectively) [p < 0.05]. After receiving noninvasive ventilation treatment, th
e hypercapnic and hypoxic responses of the hypercapnic patients increased.
At 4 to 6 weeks, values for both responses had increased to within the norm
al range and PaCO2 had fallen to < 45 mm Hg, while weight was unchanged.
Conclusions: Depressed chemoresponsiveness plays a role that is independent
of obesity in the development of CO2 retention in some OSAHS patients, and
it may be a response to sleep-disordered breathing.