Severe immune hemolytic anemia in disseminated tuberculosis with response to antituberculosis therapy

Severe hemolytic anemia in patients with disseminated tuberculosis is excee dingly rare. We report an episode of Cooms'-positive hemolytic anemia in a previously healthy young man with miliary tuberculosis, resulting in a hemo globin level of 5 g/dL and an undetectable haptoglobin level. The patient r esponded well to treatment with antituberculosis drugs, and the results of the direct Coombs' test became negative without the need of blood transfusi on or steroid therapy.