E. Klement et al., Subacute clinical forms of Plasmodium falciparum malaria in travelers receiving chloroquine-proguanil prophylaxis, CLIN INF D, 33(1), 2001, pp. E1-E2
We have observed 4 French travelers, returning from African countries, who
were not immune to malaria and were receiving chloroquine-proguanil prophyl
axis, in whom the diagnosis of malaria could easily have been missed becaus
e the clinical signs were uncommon. These cases suggest that chloroquine-pr
oguanil prophylaxis is not always effective and that travelers with unexpla
ined symptoms should be monitored closely for malaria.