Patients with acquired immunodeficiency syndrome are often susceptible
to atypical dissemination of visceral leishmaniasis. Digestive locali
zations seem to be relatively frequent. Colonic localizations reported
in the literature are endoscopically normal or show superficial mucos
al lesions. We describe an original case of leishmaniasis associated w
ith a colonic pseudotumoral stenosis with perforated ulcer penetrating
in the mesocolon. Striking inflammation of mesenteric blood vessels,
even far from the ulcer, suggested an ischemic mechanism for the colon
ic stenosis. These findings raise the hypothesis that vasculitis is se
condary to mucosal parasitic infection.