Applications of NMR in drug discovery

NMR, already some 50 years old. has long been an invaluable analytical meth od in industry for verification of chemical synthesis and compound characte risation. The range of molecular information accessible through NMR, howeve r. offers a far larger horizon of applications. Of these, ligand screening by NMR has emerged as a very promising new method in drug discovery. Its un matched screening sensitivity, combined with the abundance of available inf ormation on the structure and nature of molecular binding, justifies the gr owing interest in this dynamically expanding NMR application.