Natural-product-like chiral derivatives by solid-phase synthesis

In this genomics and proteomics age, highly functionalized natural products or natural-product-like compounds are likely to play important roles in un derstanding the functions of emerging biological targets because they serve as small-molecule chemical probes in modulating a target's specific action s (i.e. activation or deactivation). Development of stereoselective reactio n-derived methods on solid phase provides a means of obtaining functionaliz ed chiral core structures that may be used for high-throughout syntheses.