Multiple sclerosis: recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment

The cause of multiple sclerosis is generally considered to be entirely T ce ll mediated. However, recent reports of studies in a variety of animal mode ls of inflammatory demyelinating disease, coupled with detailed pathologica l analysis and neuroimaging studies of multiple sclerosis patients, indicat e that the events involved in the formation of the multiple sclerosis lesio n may be more complicated. This complex pathogenesis is reflected in the va riable response of multiple sclerosis patients to immunomodulatory therapy. Curr Opin Neurol 14:259-269. (C) 2001 Lippincott Williams & Wilkins.