Targeting the central nervous system inflammatory response in ischemic stroke

In experimental models of stroke, inflammation appears to contribute to cer ebral ischemic injury. Clinical trials that are aimed at limiting the posti schemic inflammatory response, however, have thus far had disappointing res ults. These clinical failures probably reflect the fact that there has been insufficient preclinical data and inadequate trial design, rather than pro vide evidence against a role for inflammation in ischemic brain injury. Cur r Opin Neurol 14:349-353. (C) 2001 Lippincott Williams & Wilkins.