Recent advances in the chemistry of cyclic peroxides

The well-known antimalarial properties of naturally occurring cyclic peroxi des artemisinin (qinghaosu), yingzhaosu A and yingzhaosu C have stimulated the development of new strategies for the synthesis of cyclic peroxides wit h diverse structures, and the investigation of the chemical transformations and properties of such compounds. In this review, recent progress in the c hemistry of mono- and polycyclic organic peroxides with ring sizes of five or greater is highlighted and discussed.