INTERACTION OF SOME ORGANIC PLATINUM(II) COMPLEXES WITH L5178Y-R AND L5178Y-S CELLS

The cytotoxicity and mutagenicity of three organic platinum(II) comple xes 1-3 have been studied in two strains of murine lymphoma L5178Y cel ls. (1) [Pt(Amp)Cl] (S,N,N) (Amp, ampicillin); (2) [Pt(Met(O))Cl-2] (S ,N), (met(O), L-methionine sulfoxide); (3) [Pt(Met(O))(R-IDA)] (S,N) [ N,N), (R-IDA, 2,4-N-(dimethylacetanilide)-iminodiacetic acid). It has been confirmed that the cytotoxic and mutagenic action of Pt-complexes depends on the structure of stable ligand and the number and structur e of the leaving groups. The highest cytotoxicity and mutagenicity was found in cells treated with the dichloromethioninesulfoxideplatinum(I I) complex. (C) 1997 Elsevier Science Ireland Ltd.