K. Samochocka et al., INTERACTION OF SOME ORGANIC PLATINUM(II) COMPLEXES WITH L5178Y-R AND L5178Y-S CELLS, Chemico-biological interactions, 105(2), 1997, pp. 145-155
The cytotoxicity and mutagenicity of three organic platinum(II) comple
xes 1-3 have been studied in two strains of murine lymphoma L5178Y cel
ls. (1) [Pt(Amp)Cl] (S,N,N) (Amp, ampicillin); (2) [Pt(Met(O))Cl-2] (S
,N), (met(O), L-methionine sulfoxide); (3) [Pt(Met(O))(R-IDA)] (S,N) [
N,N), (R-IDA, 2,4-N-(dimethylacetanilide)-iminodiacetic acid). It has
been confirmed that the cytotoxic and mutagenic action of Pt-complexes
depends on the structure of stable ligand and the number and structur
e of the leaving groups. The highest cytotoxicity and mutagenicity was
found in cells treated with the dichloromethioninesulfoxideplatinum(I
I) complex. (C) 1997 Elsevier Science Ireland Ltd.