Effects of cocaine prior to and during bupropion maintenance in cocaine-abusing volunteers

The effects of cocaine were examined prior to and during bupropion maintena nce in nonopioid-dependent cocaine abusers. Prior to bupropion maintenance, subjects underwent an experimental session during which repeated cocaine d oses (0, 50, 100 mg/70 kg) were administered intranasally. Then subjects we re maintained on bupropion (150 and 300 mg per day) and underwent experimen tal sessions as before. Cocaine, regardless of bupropion, produced dose-rel ated increases in several stimulant-like self-reports, performance and card iovascular measures. Bupropion decreased POMS ratings of friendliness and v igor, regardless of cocaine dose. Bupropion enhanced and attenuated cocaine -induced increases in ratings on the LSD and BG subscales of the ARCI, resp ectively. These results suggest that bupropion does not alter the acute sub jective or cardiovascular effects of cocaine in a robust manner. (C) 2001 E lsevier Science Ireland Ltd. All rights reserved.