In order to determine the prevalence and incidence of bloodborne viral infe
ctions among prisoners, we conducted a prospective study in a Danish medium
security prison for males. The prisoners were offered an interview and blo
od test for hepatitis and human immunodeficiency virus HIV at inclusion as
well as at release from prison or end of study. Of 403 prisoners available
325 (79%) participated in the initial survey and for 142 (44%) a follow-up
test was available. 43% (140/325) of the participants were injecting drug u
sers (IDUs) of whom 64% were positive for hepatitis B (HBV) and 87% for hep
atitis C (HCV) markers. No cases of HIV or human T lymphotropic virus (HTLV
) were found. 32% of all prisoners could transmit HBV and/or HCV by blood c
ontact. 70% of IDUs had shared injecting equipment, and 60% had injected in
side prison. Only 2% of IDUs were vaccinated against HBV. Duration of injec
ting drug use, numbers of imprisonments, and injecting in prison were indep
endently and positively associated with the presence of HBV antibodies amon
g IDUs by logistic regression analysis. The HBV incidence was 16/100 PY (95
% CI: 2-56/100 PY) and the HCV incidence 25/100 PY (1-140) among injecting
drug users (IDUs). We conclude that IDUs in prison have an incidence of hep
atitis B and C 100 times higher than reported in the general Danish populat
ion. They should be vaccinated against hepatitis B and new initiatives to s
top sharing of injecting equipment in and outside prison is urgently needed
.