Primary squamous cell carcinoma of the endometrium. A report of 3 cases

Primary squamous cell carcinoma of the endometrium (PSCCE) is a rare diseas e of unknown etiology. Diagnosis is based on the identification of squamous cell carcinoma in the endometrium with no coexisting analogous cervical co mponent or endometrial adenocarcinoma. There must also be no connection bet ween the endometrial tumour and the squamous epithelium of the cervix. Alth ough the majority of patients are classified as stage I disease, prognosis is rather dismal. We report two new cases of primary squamous cell carcinoma of the endometri um which fulfill all the above criteria and we discuss another interesting case of squamous cell carcinoma of questionable endometrial origin. Management by abdominal hysterectomy and adjuvant pelvic irradiation result ed in long-term survival of our patients.