Accelerated functional recovery after neuronal injury by P2 receptor blockade

Authors
Krugel, U Kittner, H Franke, H Illes, P
Citation
U. Krugel et al., Accelerated functional recovery after neuronal injury by P2 receptor blockade, EUR J PHARM, 420(2-3), 2001, pp. R3-R4
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
00142999 → ACNP
Volume
420
Issue
2-3
Year of publication
2001
Pages
R3 - R4
Database
ISI
SICI code
0014-2999(20010525)420:2-3<R3:AFRANI>2.0.ZU;2-T
Abstract
The effect of the P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2', 4'-disulphonic acid (PPADS) on changes of the quantitative electroencephalo gram (EEG) after injury of rat brain tissue was investigated. PPADS acceler ated the functional recovery from microdialysis probe-induced disturbances in the nucleus accumbens by a decrease of the ratio of absolute slow (0.6-4 Hz) to fast (8-30 Hz) power, mainly caused by a decrease in the delta freq uency power. These data provide evidence for a possible neuroprotective eff ect of P2 receptor antagonists in vivo. (C) 2001 Elsevier Science B.V. All rights reserved.