Physiological angiogenesis is a tightly regulated process that occurs mainl
y during reproduction, development and wound healing. Although angiogenesis
is a continuous process, different consecutive steps can be identified, in
cluding: i) release of pro-angiogenetic factors; ii) release of proteolytic
enzymes; iii) endothelial cell migration, morphogenesis and proliferation.
Angiogenesis is also a hallmark of malignant diseases, and an inverse corr
elation between tumor vascularity and survival was demonstrated. Thus, stra
tegies aimed at interfering with tumor blood supply by targeting tumor vasc
ulature, presently represent promising new approaches for the treatment of
solid malignancies. In fact, at least 30 angiogenetic inhibitors, utilized
alone or in combination with other therapeutic agents, are currently being
tested in clinical trials in humans. In this paper, we will review current
knowledges on selected molecules expressed by endothelial cells and involve
d in distinct steps of the angiogenetic process, that represent potential t
argets for bioimmunotherapeutic approaches in human malignancies.