Familial dyskeratotic comedones is a rare autosomal dominant genodermatosis
. In childhood or adolescence disseminated keratotic papules develop and gr
adually increase in number with time. The isolated papules show a central k
eratotic plug which tends to recur after extraction. Pruritus and occasiona
l inflammation are the only symptoms. The lesions appear on the extremities
, and less frequently on the trunk and the face. About half of the patients
have a history of acne vulgaris. The histologic picture is highly characte
ristic and shows a deep invagination of an acantholytic and dyskeratotic ep
idermis with prominent cornification. Familial dyskeratotic comedones are g
enerally refractory to any therapy. We report on two sisters with familial
dyskeratotic comedones successfully treated by CO2-laser therapy.