Familial dyskeratotic comedones. A rare entity

Citation
S. Stander et al., Familial dyskeratotic comedones. A rare entity, HAUTARZT, 52(6), 2001, pp. 533-536
Citations number
13
Categorie Soggetti
Dermatology
Journal title
HAUTARZT
ISSN journal
00178470 → ACNP
Volume
52
Issue
6
Year of publication
2001
Pages
533 - 536
Database
ISI
SICI code
0017-8470(200106)52:6<533:FDCARE>2.0.ZU;2-P
Abstract
Familial dyskeratotic comedones is a rare autosomal dominant genodermatosis . In childhood or adolescence disseminated keratotic papules develop and gr adually increase in number with time. The isolated papules show a central k eratotic plug which tends to recur after extraction. Pruritus and occasiona l inflammation are the only symptoms. The lesions appear on the extremities , and less frequently on the trunk and the face. About half of the patients have a history of acne vulgaris. The histologic picture is highly characte ristic and shows a deep invagination of an acantholytic and dyskeratotic ep idermis with prominent cornification. Familial dyskeratotic comedones are g enerally refractory to any therapy. We report on two sisters with familial dyskeratotic comedones successfully treated by CO2-laser therapy.