Histologic evaluation in rabbits of the biocompatibility of expanded silicone polytetrafluoroethylene

Purpose: To study the tolerance of a silicone band wrapped with expanded po lytetrafluoroethylene (e-PTFE) in "fauve de Bourgogne" rabbits. Methods: A 5.7mmx3.2mm band of S-PTFE (silicone-polytetrafluoroethylene, Fr ance Chirurgie Instruments) was used. A tight seal was produced between the two materials by silicone gluing. Eight eyes were implanted episclerally a nd fixed with Mersilene 5-0. One silicone band was used on a control eye. Results: Three eyes were removed at 4 weeks, one at 8 weeks and four at 12 weeks. No extrusion was observed except for the silicone band rejected 2 we eks after implantation. On histopathologic examination, PTFE colonisation w as present in all eyes with fibroblast, inflammatory cells, and neovascular ization. Conclusion: The S-PTFE implant was colonized and well tolerated in rabbit e yes. Advantages of silicone band (quality, stability of indentation) are co mbined to the tolerance of PTFE.