Interferon beta-1b retinopathy during a treatment for multiple sclerosis

Ocular adverse effects of interferon are described during the treatment of malignant diseases and chronic viral hepatitis with interferon alpha. At th is time, there is no report of these effects during multiple sclerosis trea tment with interferon beta -1b. The authors report a bilateral retinopathy during this treatment. The production of neutralizing antibodies during interferon beta -1b treatm ent leads to a decreese in diminution of therapeutic efficacy. When treatme nt failure occurs, neutralizing antibodies are to be tested.