Studying comorbidity may be particularly useful in shedding light on the na
ture, course, and management of generalized anxiety disorder (GAD). This ar
ticle reviews the common comorbidities in GAD, their impact on functioning
and on medical utilization, and their implications for treatment. Comorbidi
ty in this area is complex in that GAD may be primary (predating other illn
esses) or secondary (following other conditions). Nevertheless, studies dem
onstrate the high prevalence of patients with a matrix of anxious-somatic-d
epressive symptoms and show that GAD comorbidity is associated with both in
creased disability and increased medical utilization. Clinical implications
of this work include the need for rigorous assessment of anxiety, somatic,
and depressive symptoms in patients who present with any one of these sets
of complaints and the possibility that early treatment of GAD may be criti
cal in preventing subsequent morbidity.